We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Allergic asthma is distinguished by sensitivity of allergen-specific CD4<sup>+</sup> T cells and airway structural cells to type 2 inflammation.
- Authors
Cho, Josalyn L.; Ling, Morris F.; Adams, David C.; Faustino, Lucas; Islam, Sabina A.; Afshar, Roshi; Griffith, Jason W.; Harris, Robert S.; Aylwin Ng; Radicioni, Giorgia; Ford, Amina A.; Han, Andre K.; Xavier, Ramnik; Kwok, William W.; Boucher, Richard; Moon, James J.; Hamilos, Daniel L.; Kesimer, Mehmet; Suter, Melissa J.; Medoff, Benjamin D.
- Abstract
The article presents a study which examined the differences in airway immune response or airway structural cells during airborne allergen exposure to determine how asthma is developed in allergic individuals. Also cited are the use of allergic asthmatics (AA) and allergic nonasthmatic controls (AC) in the study, and the factors affecting allergic asthma development including the increased sensitivity of airway epithelial cells and smooth muscle to type 2 inflammation.
- Subjects
AIRWAY (Anatomy); ASTHMA risk factors; IMMUNE response; ALLERGENS; EPITHELIAL cells; PHYSIOLOGY
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 359, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aag1370