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- Title
Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy.
- Authors
Ling Zhang; Chengguang Sui; Wenhan Yang; Qiuhua Luo
- Abstract
Amino acid transporters, which play a vital role in transporting amino acids for the biosynthesis of mammalian cells, are highly expressed in types of tumors. Increasing studies have shown the feasibility of amino acid transporters as a component of tumortargeting therapy. In this review, we focus on tumor-related amino acid transporters and their potential use in tumor-targeting therapy. Firstly, the expression characteristics of amino acid transporters in cancer and their relationship with tumor growth are reviewed. Secondly, the recognition requirements are discussed, focusing on the "acidbase" properties, conformational isomerism and structural analogues. Finally, recent developments in amino acid transporter-targeting drug delivery strategies are highlighted, including prodrugs and nanocarriers, with special attention to the latest findings of molecular mechanisms and targeting efficiency of transporter-mediated endocytosis. We aim to offer related clues that might lead to valuable tumor-targeting strategies by the utilization of amino acid transporters.
- Subjects
AMINO acids; PRODRUGS; ENDOCYTOSIS; AMINO acid transport; CONFORMATIONAL isomerism; STRUCTURAL isomerism
- Publication
Asian Journal of Pharmaceutical Sciences, 2020, Vol 15, Issue 2, p192
- ISSN
1818-0876
- Publication type
Article
- DOI
10.1016/j.ajps.2019.12.002