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- Title
Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
- Authors
Christian, MacKinsey A.; Rahbar, Mohammad H.; Hessabi, Manouchehr; Lee, MinJae; Samms-Vaughan, Maureen; Shakespeare-Pellington, Sydonnie; Coore Desai, Charlene; Reece, Jody-Ann; Bressler, Jan; Grove, Megan L.; Boerwinkle, Eric; Loveland, Katherine A.
- Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
- Subjects
JAMAICA; AGE distribution; AUTISM; BREASTFEEDING; CONFIDENCE intervals; FEVER; INFECTION; ORGANIC compounds; PAINT; PESTICIDES; SEX distribution; WOUNDS &; injuries; LOGISTIC regression analysis; CASE-control method; ODDS ratio; MATERNAL exposure; PREGNANCY
- Publication
Journal of Autism & Developmental Disorders, 2018, Vol 48, Issue 8, p2766
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-018-3537-6