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- Title
A Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder.
- Authors
Bent, Stephen; Bertoglio, Kiah; Ashwood, Paul; Bostrom, Alan; Hendren, Robert L.
- Abstract
We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3-8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (±4.8) points in the omega-3 group compared to 0.3 (±7.2) points in the placebo group ( p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects.
- Subjects
CALIFORNIA; THERAPEUTIC use of omega-3 fatty acids; ANALYSIS of variance; AUTISM; CHI-squared test; CHILD behavior; CHROMATOGRAPHIC analysis; CONFIDENCE intervals; CYTOKINES; HEALTH outcome assessment; PATIENT safety; RESEARCH funding; STATISTICS; T-test (Statistics); U-statistics; PILOT projects; DATA analysis; EFFECT sizes (Statistics); RANDOMIZED controlled trials; TREATMENT effectiveness; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2011, Vol 41, Issue 5, p545
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-010-1078-8