We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease.
- Authors
Seshadri, Sudha; Fitzpatrick, Annette L.; Ikram, M. Arfan; DeStefano, Anita L.; Gudnason, Vilmundur; Boada, Merce; Bis, Joshua C.; Smith, Albert V.; Carassquillo, Minerva M.; Lambert, Jean Charles; Harold, Denise; Schrijvers, Elisabeth M. C.; Ramirez-Lorca, Reposo; Debette, Stephanie; Longstreth Jr., W. T.; Janssens, A. Cecile J. W.; Pankratz, V. Shane; Dartigues, Jean François; Hollingworth, Paul; Aspelund, Thor
- Abstract
This article discusses a study which identified additional loci associated with late-onset Alzheimer's disease (AD). White participants in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) criteria served as subjects in this study. The study compared prevalent cases in the CHARGE cohorts with controls free of dementia at the deoxyribonucleic (DNA) draw date. Results of the study showed that 973 dementia-free individuals developed incident AD over an average follow-up period of eight years. Included is a chart showing the genetic loci at which single-nucleotide polymorphisms (SNPs) associated with AD.
- Subjects
ALZHEIMER'S disease research; MEDICAL genetics; GENETIC epidemiology; DISEASE prevalence; DEMENTIA research; GENETIC polymorphism research
- Publication
JAMA: Journal of the American Medical Association, 2010, Vol 303, Issue 18, p1832
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2010.574