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- Title
Impact of Saliva and Cariogenic Microbiota on the Chemotherapy-Induced Oral Mucositis in Oncopediatric Patients: A Preliminary Longitudinal Study.
- Authors
Costa, Raphael Cavalcante; Bezerra, Paula Maria Maracajá; Damascena, Lecidamia Cristina Leite; Ribeiro, Isabella Lima Arrais; Bonan, Paulo Rogério Ferreti; Sousa, Simone Alves de; Almeida, Leopoldina de Fátima Dantas; Valença, Ana Maria Gondim
- Abstract
The aim of this study is to evaluate salivary and microbiological parameters of pediatric oncological patients and their correlation with severe oral mucositis (SOM).This study aims to evaluate the salivary parameters and cariogenic microbiota of pediatric oncological patients and their correlation with severe oral mucositis (SOM). A preliminary longitudinal study The prospective study included patients in the age range from 4 to 18 years (n = 26), with diagnosis of primary cancer, who were followed up before and after time intervals of two, five, and ten weeks of induction chemotherapy. Oral mucosa examinations were performed by means of the modified Oral Assessment Guide (OAG) by calibrated examiners (κ > 0.70). Saliva analysis (unstimulated saliva flow (USF), clinical saliva viscosity (CSV), and pH) and microbiological (total Streptococcus (TS) and Streptococcus of the mutans group (SMG)) tests were performed using unstimulated saliva. The data were analyzed by the Wilcoxon and Spearman Correlation tests (α = 5%). The patients were predominantly of the female sex (n = 15; 57.7%), adolescents (n = 15; 57.7%), and patients with hematological tumors (n = 21; 80.8%). SOM was more frequent in the tenth week (n = 7; 28.6%). The values of USF, CSV, pH, TS, and SMG were not changed by the institution of chemotherapy (p > 0.05). These values were correlated with SOM and the time, TS and SMG, and CSV and SMG. The salivary and microbiological parameters investigated did not influence the severity of oral mucositis in the pediatric patients oncological..
- Subjects
MUCOSITIS; SALIVA; LONGITUDINAL method; SALIVA analysis; ORAL mucosa; HEMATOLOGIC malignancies
- Publication
International Journal of Dentistry, 2020, p1
- ISSN
1687-8728
- Publication type
Article
- DOI
10.1155/2020/1243953