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- Title
IN-SILICO PERFORMANCE INVESTIGATION OF NANOPARTICLE-ASSISTED PHOTO THERMAL ABLATION.
- Authors
PALASH, TORIKUL ISLAM; KAYSIR, MD REJVI; ISLAM, MD JAHIRUL; AZIZ, SABIHA BINTE; MIMMA, TASKIA NADRIBA; AKTHER, NASRIN
- Abstract
In recent days, the number of cancer cases is escalating promptly around the world. In general, conventional ablation methods, encompassing comprehensive drawbacks, are employed to cure cancer. At present, photo thermal therapy (PTT) is showing great promise to the treatment of cancer. However, the effective implementation of this technology is utmost challenging as several parameters affect the tumor surroundings. In this work, the effects of different parameters on the performance of PTT have been thoroughly investigated by considering a realistic model of human tissue underneath the skin using a finite element solver, COMSOL Multiphysics. Two different conditions, with and without considering gold nanoparticles at tumor site, are investigated where a laser beam is used as a source of energy. Fluence rate, temperature distribution, and thermal damage are highlighted in this work. It is observed that by utilizing a miniature needle with integrated waveguide and gold nanoparticles, a tumor can be effectively eradicated along with assuaging the conventional drawbacks of PTT. This study would also be useful for designing operative PTT for different parts of human tissue.
- Subjects
GOLD nanoparticles; LASER beams; TEMPERATURE distribution
- Publication
Journal of Biological Systems, 2023, Vol 31, Issue 1, p93
- ISSN
0218-3390
- Publication type
Article
- DOI
10.1142/S0218339023500055