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- Title
Abnormal expression of epidermal growth factor receptor in cutaneous epithelial tumours.
- Authors
Groves, R.W.; Allen, M.H.; MacDonald, D.M.
- Abstract
Epidermal growth factor (EGF) and transforming growth factor alpha (TGF α) are important keratinocyte mitogens. Their effects are mediated by a cell membrane receptor (EGFR), quantitative and qualitative abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have therefore examined EGFR expression immunohistochemically in a variety of benign and malignant epithelial neoplasms using monoclonal antibodies to the epithelial neoplasms using monoclonal antibodies to the extracellular and intracellular receptor domains. In benign tumors (virus wart, seborrhoeic keratosis, Keratoacanthoma), there was an order pattern of EGFR expression. In malignant tumors (basal and squamous cell carcinoma), there was loss of membrane labelling and cytoplasmic accumulation of the receptor. In premalignant proliferations, there was loss of membrane receptor with either absent cytoplasmic EGFR (actinic keratosis) or cytoplasmic receptor accumulation (Bowen's disease). Evidence of truncated receptors was not found. We suggest that dysregulation of the EGFR may be important in the development of cutaneous epithelial malignancies but that grossly abnormal forms of the receptor do not occur.
- Subjects
EPITHELIAL tumors; EPIDERMAL growth factor; GROWTH factors; KERATINOCYTES; MITOGENS; MITOSIS
- Publication
Journal of Cutaneous Pathology, 1992, Vol 19, Issue 1, p66
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1992.tb01561.x