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- Title
Comparison between two bone substitutes for alveolar ridge preservation after tooth extraction: Cone‐beam computed tomography results of a non‐inferiority randomized controlled trial.
- Authors
Llanos, Alexandre Hugo; Sapata, Vítor Marques; Jung, Ronald E.; Hämmerle, Christoph H.; Thoma, Daniel S.; César Neto, João Batista; Pannuti, Claudio Mendes; Romito, Giuseppe Alexandre
- Abstract
Aim: To test the non‐inferiority of demineralized bovine bone mineral (DBBM) compared to DBBM with 10% collagen (DBBM‐C) for maintenance of bone volume after tooth extraction in the anterior maxilla. Materials and Methods: Sixty‐six patients were randomly treated with DBBM or DBBM‐C, both of which were covered with a collagen matrix for ridge preservation in the anterior maxilla. Cone‐beam computed tomographic analysis was performed immediately and 4 months after treatment. The primary outcome, for which non‐inferiority of DBBM was tested, was change in the horizontal ridge width 1 mm below the buccal alveolar crest (HW‐1) 4 months after extraction. Results: Four months after extraction, HW‐1 measured −1.60 mm ± 0.82 mm for DBBM‐C, while the DBBM group showed a mean loss of −1.37 mm ± 0.84 mm (p = 0.28, 0.23 [95% CI: −0.19; 0.64]). The horizontal ridge width at 3 mm (HW‐3) showed −0.98 mm (±0.67 mm) for DBBM‐C and −0.84 mm (±0.62 mm) for DBBM (p = 0.40, 0.12 [95% CI: −0.19; 0.45]), and the horizontal ridge width at 5 mm (HW‐5) showed −0.67 mm (±0.47 mm) for DBBM‐C and −0.56 mm (±0.48 mm) for DBBM (p = 0.36, 0.11 [95% CI: −0.13; 0.34]). Conclusions: The present clinical trial demonstrated non‐inferiority of DBBM compared to DBBM‐C for maintenance of alveolar bone volume 4 months after tooth extraction in the anterior maxilla.
- Subjects
MAXILLA surgery; BONE substitutes; COLLAGEN; COMPUTED tomography; CONFIDENCE intervals; PERIODONTITIS; POSTOPERATIVE period; DENTAL extraction; DENTAL radiography; BONE density; RANDOMIZED controlled trials
- Publication
Journal of Clinical Periodontology, 2019, Vol 46, Issue 3, p373
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13079