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- Title
Comparable Analysis of Outcomes for Allogeneic Peripheral Blood Stem Cell Transplantation from Matched Related and Matched Unrelated Donors in Acute Myeloid Leukemia.
- Authors
Lee, Soo Jung; Kang, Byung Woog; Moon, Joon Ho; Chae, Yee Soo; Kim, Jong Gwang; Jung, Joo Seop; Cho, Goon-Jae; Jo, Deog-Yeon; Kim, Yeo Kyeoung; Kim, Hyeoung Joon; Ryoo, Hun-Mo; Eom, Hyeon Seok; Le, Sang Min; Joo, Young-Don; Won, Jong-Ho; Park, Moo Rim; Kim, Min Kyung; Hyun, Myung Soo; Sohn, Sang-Kyun
- Abstract
This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7% in the unrelated PBSCT group. The cumulative incidence of extensive chronic GVHD was also higher in the unrelated PBSCT group (19.5%) than in the related PBSCT group (8.9%). The overall survival rate at 4 years was 62.4 ± 5.4 and 53.8 ± 1.2% (p = 0.535) in the related and unrelated PBSCT group, respectively. In a multivariate analysis, unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 3.019, p = 0.027). Unfavorable cytogenetics and the disease status at the time of transplantation were found to be related to overall survival. In the case of high-risk AML, the survival rate and relapse incidence were significantly better in the matched unrelated PBSCT group (p = 0.047 and 0.039, respectively). In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT. Copyright © 2011 S. Karger AG, Basel
- Subjects
STEM cell transplantation; GRAFT versus host disease; STEM cell research; TRANSPLANTATION of organs, tissues, etc.; ACUTE myeloid leukemia
- Publication
Acta Haematologica, 2012, Vol 127, Issue 2, p81
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000333133