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- Title
Correlation of MI/NAA with MMSE in Alzheimer’s Dementia.
- Authors
Ferriastuti, Widiana; Sugianto, Paulus; Notopuro, Harianto
- Abstract
Background: The delay and increase in the number of Alzheimer's dementia patients cause many impacts, both from increased morbidity and moral and material losses. Biomarkers such as brain imaging (magnetic resonance imaging (MRI) and positron emission tomography (PET) Scan) need to be done immediately in the diagnosis of suspected Alzheimer's dementia. This study aimed to analyze the relationship between the hippocampal myo-inositol (MI)/ N-acetylaspartate (NAA) ratio and the severity of Mini-Mental State Examination (MMSE) in Alzheimer's dementia patients. Methods: MMSE and Hachinski scores were assessed by a neurologist, and the hippocampal mI/NAA ratio was calculated using MRI and MR spectroscopy. Results: The right hippocampal MI/NAA was significant with the incidence of Alzheimer's (p value = 0.018). Conclusion: There was a correlation between right MI/NAA and the severity of MMSE in Alzheimer's dementia patients.
- Subjects
INDONESIA; ALZHEIMER'S disease diagnosis; BIOMARKERS; STATISTICS; HIPPOCAMPUS (Brain); CROSS-sectional method; AGE distribution; MAGNETIC resonance imaging; NUCLEAR magnetic resonance spectroscopy; MANN Whitney U Test; DISEASE incidence; DEMENTIA patients; PEARSON correlation (Statistics); DISABILITIES; POSITRON emission tomography; DATA analysis; PATH analysis (Statistics); INOSITOL; ASPARTIC acid; METABOLITES
- Publication
International Journal of Gerontology, 2023, Vol 17, Issue 2, p110
- ISSN
1873-9598
- Publication type
Article
- DOI
10.6890/IJGE.202304_17(2).0006