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- Title
Concurrent mammary adenocarcinoma and lymphoma in MNU-induced tumorigenesis in a Sprague-Dawley female rat (case report).
- Authors
Gal, A. F.; Miclăuş, V.; Taulescu, M.; Bolfa, P.; Tabaran, F.; Bouari, Cosmina; Cătoi, C.
- Abstract
N-Methyl-N-nitrosourea (MNU) induces a high incidence of mammary adenocarcinomas in Sprague-Dawley rats. Our paper describes associated mammary adenocarcinoma and malign lymphoma in mammary parenchyma in a Sprague-Dawley female rat inoculated with MNU. After a quarantine period, 20 rats were selected at random divided into 2 groups (1st and 2nd groups) and housed accordingly. 37 day old female Sprague-Dawley rats from the 1st group received a single dose of 55mg MNU/kg body weight. At 9.5 months after MNU administration the experiment was ended. Necropsy and histopathological examinations were carried out on each rat. The samples harvested for the histopathological examinations were fixed in 10% buffered formalin solution and then processed by paraffin technique. Sections were stained by Masson's trichrome and hematoxylin-eosin staining techniques. Mammary tumor induction following MNU-inoculation in the 1st group was high (90% of all tumors). In the 1st group were identified non-mammary tumors too representing about 10% of all tumors. In one individual of the 1st group were diagnosed multiple in situ mammary ductal carcinomas in several mammary glands (tumor size varied from 0.8/0.5cm to 7.9/6.5 cm). Following histological examination of all mammary tumors, a diffuse infiltrate (with lymphoblasts) extended throughout the tumor mass. The poorly differentiated lymphoblasts revealed an invasive character often bordering the tubular cancerous mammary structures. Frequently tumoral lymphoblasts induced severe compression atrophy on mammary tumor tubular structures. Based on presented histological features an unusual case with both mammary cancer and lymphoma was described in a female Sprague-Dawley rat following MNU-inoculation
- Subjects
CASE studies; ADENOCARCINOMA; LYMPHOMAS in animals; SPRAGUE Dawley rats; LABORATORY rats
- Publication
Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2012, Vol 69, Issue 1/2, p123
- ISSN
1843-5270
- Publication type
Article