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- Title
Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications.
- Authors
Cumbie, Brian C; Hermayer, Kathie L
- Abstract
Microvascular complications characterized by retinopathy, nephropathy, and neuropathy are highly prevalent among diabetics. Glycemic control has long been the mainstay for preventing progression of these complications; however, such control is not easily achieved. Currently, alternative adjunctive approaches to treating and preventing microvascular damage are being undertaken by targeting the molecular pathogenesis of diabetic complications. This review summarizes the specific pathogenic mechanisms of microvascular complications for which clinical therapies have been developed, including the polyol pathway, advanced glycation end products, protein kinase c, vascular epithelium growth factor, and the superoxide pathway. The review further focuses on therapies for these targets that are currently available or are undergoing late-stage clinical trials.
- Subjects
THERAPEUTIC use of antioxidants; DIABETES complications; VASCULAR endothelial growth factor antagonists; ANTIOXIDANTS; TRANSFERASES; OXIDOREDUCTASES; REACTIVE oxygen species; ENZYME inhibitors; PHARMACODYNAMICS; CHEMICAL inhibitors
- Publication
Vascular Health & Risk Management, 2007, Vol 3, Issue 1, p823
- ISSN
1176-6344
- Publication type
journal article