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- Title
Tumor fibroso solitario de páncreas: reporte de caso.
- Authors
Achurra Olmos, Marco Antonio; Espinosa, David; Díaz, Iván; Vergara, Ruth; Della Sera, María
- Abstract
Introduction: Solitary fibrous tumour (SFT) is a mesenchymal-derived malignant neoplasm, it can occur anywhere in the body. Lüttges et al. first described TFS affecting the pancreas. There are currently approximately 30 published cases worldwide. Case presentation: we present the case of a female patient who presented for evaluation during her puerperium due to poorly characterized epigastric discomfort and early satiety. Imaging studies revealed a lesion at the level of the pancreatic body. An attempt was made to document the etiology by biopsy, with inconclusive results, so a distal pancreatectomy was performed for diagnosis and treatment. Pathology showed solitary fibrous tumor of the pancreas. These tumors pose a diagnostic challenge at the histopathological level, so it is essential to perform immunohistochemistry to obtain an accurate diagnosis. We performed immunohistochemistry for NAB2-STAT6 showing the positivity of the test and thus establishing the diagnosis. At the molecular level the NAB2-STAT6 gene fusion encodes a protein with transcriptional activation for EGFR families, thus driving carcinogenesis. Other cases have shown association of TFS with pregnancy, however, in our case the tumor did not express hormone receptors. Conclusion: We present a clinical case with a diagnosis of solitary fibrous tumor of the pancreas, demonstrating the indispensability of immunohisto chemical tests for diagnosis. STAT6 positivity is currently the gold standard for this type of tumor. The patient is currently being followed up with no clinical or imaging data suggestive of tumor activity.
- Subjects
CHEMICAL testing; GENE fusion; HORMONE receptors; CHIMERIC proteins; DIAGNOSTIC imaging
- Publication
Revista Médica de Panamá, 2023, Vol 43, Issue 3, p171
- ISSN
0379-1629
- Publication type
Case Study
- DOI
10.37980/im.journal.rmdp.20232230