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- Title
A Spotlight on the Underlying Activation Mechanisms of the NLRP3 Inflammasome and its Role in Atherosclerosis: A Review.
- Authors
Liaqat, Anam; Asad, Muhammad; Shoukat, Fatima; Khan, Arif-Ullah
- Abstract
The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contributes to the underlying pathology. Therefore, therapeutic targeting of inflammatory pathways in patients with cardiovascular diseases such as atherosclerosis enhances cardiovascular results. Inflammasomes are intracellular protein complexes engaged in atherosclerosis pathogenesis and activated by multiple danger signals. Emerging proof has revealed that Nod-like receptor protein 3 (NLRP3) inflammasome, which regulates caspase-1 activation and later pro-interleukin processing, triggers inflammatory reactions in the vascular wall and leads to atherosclerotic plaque formation. Inflammasome-mediated signaling interference could decrease inflammation and mitigate illness severity. In this section, we provide an overview of the present literature on the underlying mechanisms leading to the activation of NLRP3 inflammasome and the role of NLRP3 inflammasome in the progression of atherogenesis and highlight the possibility of therapeutic interventions due to mechanisms involved in the of inhibition of NLRP3 activation.
- Subjects
ATHEROSCLEROSIS; ATHEROSCLEROTIC plaque; PATHOLOGY; ETIOLOGY of diseases; CARDIOVASCULAR diseases; PROTEIN receptors; INFLAMMASOMES
- Publication
Inflammation, 2020, Vol 43, Issue 6, p2011
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-020-01290-1