We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Copper‐Catalyzed Ring‐Opening (3+2) Annulation of Cyclopropenones with Ketoxime Acetates: Access to 1,2‐Dihydro‐pyrrol‐3‐ones Bearing a Quaternary Carbon Center.
- Authors
Wang, Zhen‐Hua; Yang, Ping; Zhang, Yan‐Ping; You, Yong; Zhao, Jian‐Qiang; Zhou, Ming‐Qiang; Yuan, Wei‐Cheng
- Abstract
A Cu(I)‐catalyzed ring‐opening (3+2) annulation of cyclopropenones with ketoxime acetates has been developed. In disclosed protocol, ketoxime acetates are selected as C−N splicing unit to participate in the transformation process, furnishing a sequence of highly functional 1,2‐dihydro‐pyrrol‐3‐one derivatives in good isolated yields. Besides, scale‐up reaction is conducted to demonstrate the practicability of developed methodology and a tentative mechanism for (3+2) annulation is also proposed.
- Subjects
ANNULATION; CARBON
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 18, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202200110