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- Title
Catalytic N-Acylation of Cyclic Amines by Arylglyoxylic Acids via Radical-Radical Cross-Coupling.
- Authors
Rahaman, Ajijur; Singh, Anupam Kumar; Gupta, Aniket; Bhadra, Sukalyan
- Abstract
A methodical mechanistic investigation allowed for the catalytic N-acylation of secondary cyclic amine counterparts by arylglyoxylic acids through radical-radical coupling. The reaction proceeds via a twofold SET-promoted Cu(I)/Cu(II) catalytic cycle under mild conditions. An analogous reaction variant allows for the N-acylation in a one-pot fashion directly starting from a secondary cyclic amine even in the presence of a second amine or hydroxy group.
- Subjects
SECONDARY amines; ACIDS; AMINES
- Publication
European Journal of Organic Chemistry, 2021, Vol 2021, Issue 15, p2198
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202100381