We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Rhodium(III)‐Catalyzed C–H Alkylation/Nucleophilic Addition Domino Reaction.
- Authors
Tang, Mengyao; Li, Yunpeng; Han, Shengnan; Liu, Lei; Ackermann, Lutz; Li, Jie
- Abstract
A C–H alkylation/nucleophilic addition manifold with synthetically useful aryl oximes and pyrazoles was realized by rhodium(III) catalysis under remarkably mild reaction conditions. Valuable β‐acyl substituted arylbutanoates were obtained in moderate to good yields. This strategy is characterized by excellent atom‐ and step‐economy, high chemo‐ and site‐selectivity, a broad substrate scope, and a wide functional group tolerance. A straightforward approach to the synthesis of valuable β‐acyl substituted arylbutanoates has been developed through a rhodium(III)‐catalyzed three‐component C–H alkylation/nucleophilic addition manifold with synthetically useful aryl oximes and pyrazoles under mild reaction conditions.
- Subjects
ALKYLATION; NUCLEOPHILIC catalysis; FUNCTIONAL groups; RHODIUM; OXIMES
- Publication
European Journal of Organic Chemistry, 2019, Vol 2019, Issue 4, p660
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201801535