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- Title
Prevotella denticola Lipopolysaccharide from a Cystic Fibrosis Isolate Possesses a Unique Chemical Structure.
- Authors
Di Lorenzo, Flaviana; Silipo, Alba; Matier, Thomas; Hanuszkiewicz, Anna; Elborn, J. Stuart; Lanzetta, Rosa; Sturiale, Luisa; Scamporrino, Andrea; Garozzo, Domenico; Valvano, Miguel A.; Tunney, Michael M.; Molinaro, Antonio
- Abstract
We report the first complete structural characterization of the lipopolysaccharide (LPS) from a cystic fibrosis (CF) clinical isolate of Prevotella denticola (B003V1S1X). Chemical, spectroscopic, and spectrometric analyses revealed a unique rough-type LPS (LOS) structure. The structure has a highly negatively charged heptasaccharide core region containing hexoses, with the first two sugars, 3-deoxy- D- manno-oct-2-ulosonic acid (Kdo) and mannose, highly phosphorylated. Furthermore, the lipid A moiety has the typical structure for the genus Prevotella, and was also highly phosphorylated.
- Subjects
PREVOTELLA; ENDOTOXINS; CYSTIC fibrosis; CHEMICAL structure; SPECTRUM analysis; HEXOSES
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 9, p1732
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201600037