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- Title
Exercise Chronotropy in Patients with Normal and Impaired Sinus Node Function After Cardiac Transplantation.
- Authors
Heinz, Gottfried; Radosztics, Susanne; Kratochwill, Christoph; Kreiner, Gerhard; Buxbaum, Peter; Grimm, Michael; Sunder-Plassmann, Gene; Lauferi, Günther; Laczkovics, Axel; Gossinger, Heinz
- Abstract
The chronotropic response during graded, symptom limited exercise was investigated in 32 cardiac transplant recipients a mean of 49 ± 18 days after transplantation. Ail patients had systematic evaluation of postoperative donor sinus node (SN) function and the cardioacceleratory response was compared according to the SN /unction. Twenty-one patients had normal postoperative SN studies (corrected SN recovery time < 520 msec, group I) while the SN function was impaired postoperatively in the remainder (n = 11, group H, corrected SN recovery time 4,149 ± 6,283 msec in 5 patients, junctionai escape rhythm in 6 patients). All patients had regained sinus rhythm at time of the exercise test. Patients in group II had lower basal sinus rates at the beginning of exercise (91.5 ± 11 vs 101.4 ± 7 beats/min, P < 0.02). This lower chronotropy was maintained over every incremental step [Frate between groups = 30, P = 0.0001, Frate vs workload = 15,P = 0.0001 by two-way ANOVA] and resulted in a significantly lower heart rate at individual peak exercise (108.3 ± 20 vs 124.2 ± 13 beats/min, P < 0.02). A total of 14/16 patients in group I but only 2/16 patients in group 11 accomplished a peak heart rate > 120 beats/min (P = 0.009). The workload achieved did not differ between the groups {107 ± 29 vs 102 ± 32 watts, P > 0.5). These data show a lower SN chronotropy during rest and at peak exercise in cardiac transplant recipients with postoperative SN deficiency and apparent normalization of SN function.
- Subjects
HEART transplantation; CARDIAC surgery; EXERCISE; SINOATRIAL node; TRANSPLANTATION of organs, tissues, etc.
- Publication
Pacing & Clinical Electrophysiology, 1993, Vol 16, Issue 9, p1793
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.1993.tb01813.x