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- Title
Identification of Tools to Measure Changes in Musculoskeletal Symptoms and Physical Functioning in Women With Breast Cancer Receiving Aromatase Inhibitors.
- Authors
Swenson, Karen K.; Nissen, Mary Jo; Henly, Susan J.; Maybon, Laura; Pupkes, Jean; Zwicky, Karen; Tsai, Michaela L.; Shapiro, Alice C.
- Abstract
Purpose/Objectives: To estimate and compare responsiveness of standardized self-reported measures of musculoskeletal symptoms (MSSs) and physical functioning (PF) during treatment with aromatase inhibitors (AIs).Design: Prospective, longitudinal study.Setting: Park Nicollet Institute and North Memorial Cancer Center, both in Minneapolis, MN.Sample: 122 postmenopausal women with hormone receptor-positive breast cancer.Methods: MSSs and PF were assessed before starting AIs and at one, three, and six months using six self-reported MSSs measures and two PF tests.Main Research Variables: MSSs and PF changes from baseline to six months.Findings: Using the Breast Cancer Prevention Trial-Musculoskeletal Symptom (BCPT-MS) subscale, 54% of participants reported MSSs by six months. Scores from the BCPT-MS subscale and the physical function subscales of the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and Western Ontario and McMaster Osteoarthritis Index (WOMAC) were most responsive to changes over six months.Conclusions: BCPT-MS, AUSCAN, and WOMAC were the most responsive instruments for measuring AI-associated MSSs.Implications for Nursing: Assessment and management of MSSs are important aspects of oncology care because MSSs can affect functional ability and AI adherence.Knowledge Translation: The three measures with the greatest sensitivity were the BCPT-MS, AUSCAN, and WOMAC questionnaires. These measures will be useful when conducting research on change in MSSs associated with AI treatment in women with breast cancer.
- Subjects
MINNESOTA; AROMATASE inhibitors; BREAST tumors; CHI-squared test; GRIP strength; LONGITUDINAL method; MUSCULOSKELETAL system diseases; QUESTIONNAIRES; RESEARCH funding; SELF-evaluation; T-test (Statistics); SAMPLE size (Statistics); EFFECT sizes (Statistics); PAIN measurement; BODY mass index; SEVERITY of illness index; POSTMENOPAUSE; DATA analysis software; FUNCTIONAL assessment; DESCRIPTIVE statistics; SYMPTOMS; THERAPEUTICS
- Publication
Oncology Nursing Forum, 2013, Vol 40, Issue 6, p549
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/13.ONF.549-557