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- Title
Synthesis and characterization of poly(ethylene glycol)- b-poly(ε-caprolactone) copolymers with functional side groups on the polyester block.
- Authors
Chen, Wen-Hsin; Hua, Mu-Yi; Lee, Ren-Shen
- Abstract
This study reports the successful synthesis of amphiphilic MPEG- b-PCL based-block copolymers bearing benzyloxy and hydroxyl side groups on the PCL block by ring-opening polymerization of 4-benzyloxy-ε-caprolactone (4-BOCL) and ε-caprolactone (ε-CL) with methoxy PEG (550 g mol−1) as the initiator and Tin(II) 2-ethylhexanoate (SnOct2) as the catalyst. These copolymers were characterized by differential scanning calorimetry (DSC), 1H NMR, and gel permeation chromatography. The thermal properties ( T g and T ms) of the block copolymers depend on the polymer composition. Incorporating a greater amount of 4-BOCL and/or ε-CL was incorporated into the macromolecular backbone causes a decrease T g, and an increase in T ms. The micellar characteristics in the aqueous phase were investigated by fluorescence spectroscopy, transmission electron microscopy (TEM), and dynamic light scattering (DLS). A lower critical micelle concentration (CMC) was observed in MPEG12- b-PBOCL12- b-PCL series, which have higher hydrophobic components in the copolymers. However, contrasting results were observed for MPEG12- b-PBOCL27- b-PCL systems. The micelle exhibited a spindle shape, with an average size of less than 200 nm. A weak drug entrapment efficiency and drug-loading ability of these micelles were observed. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
- Subjects
POLYETHYLENE glycol; COPOLYMERS; HYDROXYLATION; RING-opening polymerization; BLOCK copolymers; MICELLES
- Publication
Journal of Applied Polymer Science, 2012, Vol 125, Issue 4, p2902
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.36225