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- Title
Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.
- Authors
González‐Valderrama, Alfonso; Castañeda, Carmen Paz; Mena, Cristián; Undurraga, Juan; Mondaca, Pilar; Yañez, Matías; Bedregal, Paula; Nachar, Ruben
- Abstract
Aim To determine the association between duration of untreated psychosis ( DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. Methods Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. Results Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group ( P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission ( HR: 3.04, 95% CI 1.2-7.5). Conclusions DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
- Subjects
PSYCHOSES; SCHIZOPHRENIA; DISEASE remission; EARLY medical intervention; SYMPTOMS; PROGNOSIS
- Publication
Early Intervention in Psychiatry, 2017, Vol 11, Issue 1, p77
- ISSN
1751-7885
- Publication type
Article
- DOI
10.1111/eip.12266