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- Title
Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda.
- Authors
Li Ying Tan; Yin, Wai-Fong; Chan, Kok-Gan
- Abstract
Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
- Subjects
QUORUM sensing; MELICOPE; BACTERIOPHAGES; PATHOGENIC microorganisms; ENDEMIC plants; BIOLUMINESCENCE; CHROMOBACTERIUM violaceum; PSEUDOMONAS aeruginosa
- Publication
Sensors (14248220), 2012, Vol 12, Issue 4, p4339
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s120404339