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- Title
Serum Gastrin is Not Higher in Subjects with Colonic Neoplasia1.
- Authors
Kikendall, James Walter; Glass, Allan R.; Sobin, Leslie H.; Bowen, Phyllis E.
- Abstract
Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinomas (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia.
- Subjects
GASTRIN; COLON tumors; GASTROINTESTINAL hormones; GASTRIC secretions; RADIOIMMUNOASSAY
- Publication
American Journal of Gastroenterology (Springer Nature), 1992, Vol 87, Issue 10, p1394
- ISSN
0002-9270
- Publication type
Article