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- Title
Reversibility of Increased Intestinal Permeability to <sup>51</sup>Cr-EDTA in Patients with Gastrointestinal Inflammatory Diseases.
- Authors
Jenkins, R. T.; Jones, D. B.; Goodacre, R. L.; Collins, S. M.; Coates, G.; Hunt, R. H.; Bienenstock, J.
- Abstract
Intestinal permeability in adults with inflammatory gastrointestinal diseases was investigated by measuring the 24-h urinary excretion of orally administered 51Cr-EDTA. Eighty controls along with 100 patients with Crohn's disease, 46 patients with ulcerative colitis, 20 patients with gluten-sensitive enteropathy, and 18 patients with other diseases were studied. In controls, the median 24-h excretion was 1.34%/24 h of the oral dose. Patients with Crohn's disease (median 2.96%/24 h), ulcerative colitis (median 2.12%/24 h), and untreated gluten-sensitive enteropathy (median 3.56%/24 h) had significantly elevated urinary excretion of the probe compared to controls (<em>p</em> < 0.0001). Increased 24-h urinary excretion of 51Cr-EDTA had a high association with intestinal inflammation (<em>p</em> < 0.0001). Test specificity and sensitivity were 96% and 57%, respectively. A positive test has a 96% probability of correctly diagnosing the presence of intestinal inflammation, whereas a negative test has a 50% probability of predicting the absence of disease.
- Subjects
INTESTINAL absorption; GASTROINTESTINAL diseases; CROHN'S disease; ULCERATIVE colitis; INFLAMMATORY bowel diseases; PATIENTS
- Publication
American Journal of Gastroenterology (Springer Nature), 1987, Vol 82, Issue 11, p1159
- ISSN
0002-9270
- Publication type
Article