We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Differential neuronal susceptibility and apoptosis in congenital Zika virus infection.
- Authors
Ho, Cheng‐Ying; Ames, Heather M.; Tipton, Ashley; Vezina, Gilbert; Liu, Judy S.; Scafidi, Joseph; Torii, Masaaki; Rodriguez, Fausto J.; du Plessis, Adre; DeBiasi, Roberta L.
- Abstract
To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although ZIKV demonstrated a wide range of neuronal and non-neuronal tropism, the infection rate was highest in intermediate progenitor cells and immature neurons. Apoptosis was observed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis. Our results highlight differential neuronal susceptibility and neuronal apoptosis as potential mechanisms in the development of ZIKV-associated microcephaly, and may provide insights into the design and best timing of future therapy. Ann Neurol 2017;82:121-127.
- Subjects
ZIKA virus infections; APOPTOSIS; DISEASE susceptibility; MICROCEPHALY; PROGENITOR cells; NEURONS; DISEASES; BRAIN
- Publication
Annals of Neurology, 2017, Vol 82, Issue 1, p121
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.24968