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- Title
Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians.
- Authors
Joo-Yeon Hwang; Xueling Sim; Ying Wu; Jun Liang; Yasuharu Tabara; Cheng Hu; Kazuo Hara; Tam, Claudia H. T.; Qiuyin Cai; Qi Zhao; Sunha Jee; Fumihiko Takeuchi; Min Jin Go; Rick Twee Hee Ong; Takayoshi Ohkubo; Young Jin Kim; Rong Zhang; Toshimasa Yamauchi; Wing Yee So; Jirong Long
- Abstract
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
- Subjects
GLUCOSE intolerance; METABOLIC disorders; HUMAN population genetics; GLUCOSE metabolism disorders; BLOOD sugar; GENOMES; EAST Asians; GENETICS; HEALTH
- Publication
Diabetes, 2015, Vol 64, Issue 1, p291
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db14-0563