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- Title
Exercise versus Diet dominant Weight Loss in Type 2 Diabetes: Different Effects on Visceral Fat and Insulin Sensitivity.
- Authors
Kyung Ah Han; Hyo-Jeong Kim; Hyun Jin Kim; Kang Seo Park; Kyung Wan Min; Eung Jin Kim
- Abstract
Reductions in visceral fat hve been shown to improve glucose tolerance and insulin sensitivity. We investigated the effects of exercise and diet dominant weight reduction on visceral fat mass and insulin sensitivity in type 2 diabetes. Sixty overweight and obese female patients with type 2 diabetes were recruited for 12 week weight reduction program (age: 55.3±8.5 years; body mass index(BMI): 27.8±5.6 kg/m²). Twenty patients were randomly assigned to each three group; control, diet-dominant weight reduction group(DG), and exercise-dominant weight reduction group(EG). DG was recommended for low calorie diet which was calculated with 25 kcal per kg of ideal body weight and EG was encouraged to walk about 2 hours, aiming at 300 kcal of exercise energy expenditure, individually prescribed by exercise physiologist. The calorie intake were monitored with 24 hour recall and energy expenditure with accelerometer (Lifecorder [sup R]) at every 2 weeks. We measured anthropometric parameters, visceral fat(VF), subcutaneous fat (SF), and total fat (TF) area by computed tomography, and insulin-sensitivity index scores expressed as Kitt (percent decline in plasma glucose concentration per minute after bolus of regular human insulin) before and after trial. Nine subjects dropped out and data from 51 subjects were analyzed. Compared to baseline, BMI were decreased in all three groups. VF and SF decreased in DG, VF decrease in EG after trial. In comparison of three groups, percent VF was decreased and Kitt was increased significantly only in EG, after adjusted for age, glycemic control and lipid level, while percent change of BMI, TF and SF is significantly decreased in DG. These data suggested that exercise might be more beneficial to negative energy balance from calorie restriction in preferential loss of visceral fat and insulin resistance in Type 2 diabetes.
- Subjects
EXERCISE; DIET; WEIGHT loss; TYPE 2 diabetes; INSULIN; BODY mass index; INSULIN resistance
- Publication
Diabetes, 2007, Vol 56, pA639
- ISSN
0012-1797
- Publication type
Article