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- Title
Impaired Angiogenic Function of Fetal Endothelial Progenitor Cells via PCDH10 in Gestational Diabetes Mellitus.
- Authors
Kwon, Hayan; Jung, Yun Ji; Lee, Yeji; Son, Ga-Hyun; Kim, Hyun Ok; Maeng, Yong-Sun; Kwon, Ja-Young
- Abstract
Maternal hyperglycemia, induced by gestational diabetes mellitus (GDM), has detrimental effects on fetal vascular development, ultimately increasing the risk of cardiovascular diseases in offspring. The potential underlying mechanisms through which these complications occur are due to functional impairment and epigenetic changes in fetal endothelial progenitor cells (EPCs), which remain less defined. We confirm that intrauterine hyperglycemia leads to the impaired angiogenic function of fetal EPCs, as observed through functional assays of outgrowth endothelial cells (OECs) derived from fetal EPCs of GDM pregnancies (GDM-EPCs). Notably, PCDH10 expression is increased in OECs derived from GDM-EPCs, which is associated with the inhibition of angiogenic function in fetal EPCs. Additionally, increased PCDH10 expression is correlated with the hypomethylation of the PCDH10 promoter. Our findings demonstrate that in utero exposure to GDM can induce angiogenic dysfunction in fetal EPCs through altered gene expression and epigenetic changes, consequently increasing the susceptibility to cardiovascular diseases in the offspring of GDM mothers.
- Subjects
GESTATIONAL diabetes; PROGENITOR cells; ENDOTHELIAL cells; FETAL death; GENE expression; CARDIOVASCULAR diseases
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 22, p16082
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242216082