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- Title
IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
- Authors
Park, Hyun Jung; Lee, Sung Won; Van Kaer, Luc; Lee, Myeong Sup; Hong, Seokmann
- Abstract
Interleukin-7 (IL-7) plays a vital role in the homeostasis of CD4+ and CD8+ T cells. Although IL-7 has been implicated in T helper (Th)1- and Th17-mediated autoinflammatory diseases, its role in Th2-type allergic disorders, such as atopic dermatitis (AD), remains unclear. Thus, to elucidate the effects of IL-7 deficiency on AD development, we generated IL-7-deficient AD-prone mice by backcrossing IL-7 knockout (KO) B6 mice onto the NC/Nga (NC) mouse strain, a model for human AD. As expected, IL-7 KO NC mice displayed defective development of conventional CD4+ and CD8+ T cells compared with wild type (WT) NC mice. However, IL-7 KO NC mice presented with enhanced AD clinical scores, IgE hyperproduction, and increased epidermal thickness compared with WT NC mice. Moreover, IL-7 deficiency decreased Th1, Th17, and IFN-γ-producing CD8+ T cells but increased Th2 cells in the spleen of NC mice, indicating that a reduced Th1/Th2 ratio correlates with severity of AD pathogenesis. Furthermore, significantly more basophils and mast cells infiltrated the skin lesions of IL-7 KO NC mice. Taken together, our findings suggest that IL-7 could be a useful therapeutic target for treating Th2-mediated skin inflammations, such as AD.
- Subjects
ATOPIC dermatitis; TH2 cells; MICE; SKIN inflammation; MAST cells; T cells; HOMEOSTASIS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 12, p9956
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24129956