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- Title
Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets.
- Authors
di Meo, Nicola Antonio; Lasorsa, Francesco; Rutigliano, Monica; Loizzo, Davide; Ferro, Matteo; Stella, Alessandro; Bizzoca, Cinzia; Vincenti, Leonardo; Pandolfo, Savio Domenico; Autorino, Riccardo; Crocetto, Felice; Montanari, Emanuele; Spilotros, Marco; Battaglia, Michele; Ditonno, Pasquale; Lucarelli, Giuseppe
- Abstract
Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer subtype. Over the last decade, significant progress has been made in identifying the genetic and metabolic alterations driving ccRCC development. In particular, an integrated approach using transcriptomics, metabolomics, and lipidomics has led to a better understanding of ccRCC as a metabolic disease. The metabolic profiling of this cancer could help define and predict its behavior in terms of aggressiveness, prognosis, and therapeutic responsiveness, and would be an innovative strategy for choosing the optimal therapy for a specific patient. This review article describes the current state-of-the-art in research on ccRCC metabolic pathways and potential therapeutic applications. In addition, the clinical implication of pharmacometabolomic intervention is analyzed, which represents a new field for novel stage-related and patient-tailored strategies according to the specific susceptibility to new classes of drugs.
- Subjects
RENAL cell carcinoma; METABOLIC disorders; DRUG target; RENAL cancer; LIPIDOMICS
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 22, p14360
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232214360