We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents.
- Authors
Wróbel, Tomasz M.; Rogova, Oksana; Andersen, Kasper L.; Yadav, Rahul; Brixius-Anderko, Simone; Scott, Emily E.; Olsen, Lars; Jørgensen, Flemming Steen; Björkling, Fredrik
- Abstract
The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhibitors (sub µM) with antiproliferative activity in prostate cancer cell lines. The binding mode of these compounds is also discussed.
- Subjects
CYTOCHROME P-450; PROSTATE cancer; ENZYME inhibitors; CELL lines; CANCER cells
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 14, p4868
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21144868