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- Title
Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents.
- Authors
Lee, Eun-Soo; Ahn, Yujin; Bae, Il-Hong; Min, Daejin; Park, Nok Hyun; Jung, Woonggyu; Kim, Se-Hwa; Hong, Yong Deog; Park, Won Seok; Lee, Chang Seok
- Abstract
The outer epidermal skin is a primary barrier that protects the body from extrinsic factors, such as ultraviolet (UV) radiation, chemicals and pollutants. The complete epithelialization of a wound by keratinocytes is essential for restoring the barrier function of the skin. However, age-related alterations predispose the elderly to impaired wound healing. Therefore, wound-healing efficacy could be also considered as a potent function of an anti-aging reagent. Here, we examine the epidermal wound-healing efficacy of the fourth-generation retinoid, seletinoid G, using HaCaT keratinocytes and skin tissues. We found that seletinoid G promoted the proliferation and migration of keratinocytes in scratch assays and time-lapse imaging. It also increased the gene expression levels of several keratinocyte proliferation-regulating factors. In human skin equivalents, seletinoid G accelerated epidermal wound closure, as assessed using optical coherence tomography (OCT) imaging. Moreover, second harmonic generation (SHG) imaging revealed that seletinoid G recovered the reduced dermal collagen deposition seen in ultraviolet B (UVB)-irradiated human skin equivalents. Taken together, these results indicate that seletinoid G protects the skin barrier by accelerating wound healing in the epidermis and by repairing collagen deficiency in the dermis. Thus, seletinoid G could be a potent anti-aging agent for protecting the skin barrier.
- Subjects
WOUND healing; SECOND harmonic generation; OPTICAL coherence tomography; POLLUTANTS; COLLAGEN; SKIN
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 9, p3198
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21093198