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- Title
Application of the Scorpion Neurotoxin AaIT against Insect Pests.
- Authors
Deng, Sheng-Qun; Chen, Jia-Ting; Li, Wen-Wen; Chen, Min; Peng, Hong-Juan
- Abstract
Androctonus australis Hector insect toxin (AaIT), an insect-selective toxin, was identified in the venom of the scorpion Androctonus australis. The exclusive and specific target of the toxin is the voltage-gated sodium channels of the insect, resulting in fast excitatory paralysis and even death. Because of its strict toxic selectivity and high bioactivity, AaIT has been widely used in experiments exploring pest bio-control. Recombinant expression of AaIT in a baculovirus or a fungus can increase their virulence to insect pests and diseases vectors. Likewise, transgenic plants expressing AaIT have notable anti-insect activity. AaIT is an efficient toxin and has great potential to be used in the development of commercial insecticides.
- Subjects
INSECT pests; SODIUM channels; SCORPIONS; BIOLOGICAL pest control; INSECT diseases; DISEASE vectors
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 14, p3467
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20143467