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- Title
miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway.
- Authors
Renqiao Tang; Feifei Ma; Wei Li; Shengrong Ouyang; Zhuo Liu; Jianxin Wu
- Abstract
MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an apparent decreasing trend after induction, and sustained low expression throughout the differentiation of 3T3-L1 cells. miR-206-3p blocked the adipogenic differentiation of 3T3-L1 cells by attenuating c-Met expression; the inhibition effect of miR-206 to the adipogenic differentiation can be counteracted by restoring c-Met expression. In addition, miR-206-3p decreased the phosphorylation of Akt, which is the downstream effector of c-Met in the PI3K/Akt signaling pathway. These data indicate that miR-206-3p inhibits adipocyte adipogenesis through silencing c-Met and subsequently inactivating the PI3K/Akt signaling pathway.
- Subjects
ADIPOGENESIS; MICRORNA; FAT cells; CELLULAR signal transduction; CELL differentiation
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 7, p1510
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18071510