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- Title
Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment.
- Authors
Hendrix, An; De Wever, Olivier
- Abstract
The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.
- Subjects
EXOSOMES; CANCER cells; CANCER invasiveness; STROMAL cells; BONE marrow; EXTRACELLULAR matrix
- Publication
International Journal of Molecular Sciences, 2013, Vol 14, Issue 5, p9883
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms14059883