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- Title
Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different?
- Authors
Kherabi, Yousra; Zeller, Valérie; Kerroumi, Younes; Meyssonnier, Vanina; Heym, Beate; Lidove, Olivier; Marmor, Simon
- Abstract
<bold>Background: </bold>Staphylococci and streptococci are the most frequent pathogens isolated from prosthetic joint infections (PJIs). The aim of this study was to analyze the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) PJIs.<bold>Methods: </bold>All monomicrobial streptococcal and MSSA PJIs managed in a French Referral Center (2010-2017) were sampled from the prospective PJIs cohort study. The primary outcome of interest was the cumulative reinfection-free survival at a 2-year follow-up.<bold>Results: </bold>Two hundred and nine patients with 91 streptococcal and 132 staphylococcal infections were analyzed. Patients with streptococcal PJI were older, and infection was more frequently hematogenous. Reinfection-free survival rates at 2-years after all treatment strategies were higher for patients with streptococcal PJI (91% vs 81%; P = .012), but differed according to the strategy. After exchange arthroplasty, no outcome differences were observed (89% vs 93%; P = .878); after debridement, antibiotics and implant retention (DAIR), the reinfection-free survival rate was higher for patients with streptococcal PJI (87% vs 60%; P = .062). For patients managed with prolonged suppressive antibiotic therapy (SAT) alone, those with streptococcal PJIs had a 100% infection-free survival (100% vs 31%; P < .0001).<bold>Conclusions: </bold>Reinfection-free survival after DAIR and SAT was better for patients with streptococcal than those with MSSA PJIs. No difference was observed after prosthesis exchange.
- Subjects
ANTIBIOTICS; PROSTHETICS; INFECTIOUS arthritis; DEBRIDEMENT; ARTIFICIAL implants; RETROSPECTIVE studies; STAPHYLOCOCCAL diseases; INFECTION; TREATMENT effectiveness; STREPTOCOCCUS; STAPHYLOCOCCUS aureus; PROSTHESIS-related infections; LONGITUDINAL method
- Publication
BMC Infectious Diseases, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-022-07532-x