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- Title
Normal values for pancreatic stone protein in different age groups.
- Authors
Schlapbach, Luregn J.; Giannoni, Eric; Wellmann, Sven; Stocker, Martin; Ammann, Roland A.; Graf, Rolf
- Abstract
Background: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP. Methods: PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations. Results: PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %). Conclusions: This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood.
- Subjects
SWITZERLAND; AGE distribution; BIOMARKERS; ENZYME-linked immunosorbent assay; NEONATAL intensive care; PANCREAS; PROBABILITY theory; PROTEINS; REFERENCE values; SEPSIS; NEONATAL intensive care units; DATA analysis software; MANN Whitney U Test
- Publication
BMC Anesthesiology, 2015, Vol 15, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-015-0149-y