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- Title
Citotoxicidad In Vitro del Mercurio sobre Leucocitos Polimorfonucleares.
- Authors
Soto Gómez, Musseta Elena; Tinoco Cabrioles, Violeta Cecilia; Isassi Hernández, Hilda; Padilla Corona, Juventino; Trejo Tejeda, Sergio E.; Parra, Rogelio Oliver; Huitzil Muñoz, Enrique E.
- Abstract
Dental amalgam has been usually used as the selective material in dentals restorations, alloy consisting mainly of silver, tin, copper and zinc materials which are found mixed with the Mercury. Mercury is a chemical element (metal) naturally in the environment and the people could be exposed to mercury in their diet, water, pollution and dental amalgams. People with amalgam fillings are chronically exposed to low doses of mercury. In this paper an interesting material to research is presented looking potentially effect that mercury could do on the neutrophil polymorphonuclear leukocytes. Objective. The aim of this study was to evaluate the In-Vitro Cytotoxicity from HgCI2 (mercury chloride) on LPMN. Materials and methods. 10ml of blood sample was taken from clinical healthy volunteer donors and their neutrophil polymorphonuclear leukocytes were separated and the population was adjusted and challenged with HgCI2 solution l0mM for one hour and 2 hours keeping the following concentrations: 2µg/ml, 4µg/ml, 6µg/ml, 12 ug/ml. Results. The results were obtained using the SPSS version 18.0 Statistic were that at concentrations of 12ug /ml the mercury chloride affected the viability of neutrophil polymorphonuclear leukocytes following a dose-response pattern where concentration (12µg/ml HgCI2) affected the viability of neutrophil polymorphonuclear leukocyte. Conclusions. The results showed a response the higher concentration (12µg/ml HgCI2) lower viability.
- Subjects
DENTAL amalgams; MERCURY; OPERATIVE dentistry; DENTAL fillings; INLAYS (Dentistry); HAZARDOUS substances; HAZARDOUS substance exposure
- Publication
Revista Oral, 2014, Vol 15, Issue 47, p1070
- ISSN
1665-143X
- Publication type
Article