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- Title
Reduction of adult hippocampal neurogenesis is amplified by aluminum exposure in a model of type 2 diabetes.
- Authors
Sung Min Nam; Jong Whi Kim; Dae Young Yoo; Hyo Young Jung; Jung Hoon Choi; In Koo Hwang; Je Kyung Seong; Yeo Sung Yoon
- Abstract
In this study, we investigated the effects of chronic aluminum (Al) exposure for 10 weeks on cell proliferation and neuroblast differentiation in the hippocampus of type 2 diabetic rats. Six-week-old Zucker diabetic fatty (ZDF) and Zucker lean control (ZLC) rats were selected and randomly divided into Al- and non-Al-groups. Al was administered via drinking water for 10 weeks, after which the animals were sacrificed at 16 weeks of age. ZDF rats in both Al- and non-Al-groups showed increases in body weight and blood glucose levels compared to ZLC rats. Al exposure did not significantly affect body weight, blood glucose levels or pancreatic β-cells and morphology of the pancreas in either ZLC or ZDF rats. However, exposure to Al reduced cell proliferation and neuroblast differentiation in both ZLC and ZDF rats. Exposure to Al resulted in poor development of the dendritic processes of neuroblasts in both ZLC and ZDF rats. Furthermore, onset and continuation of diabetes reduced cell proliferation and neuroblast differentiation, and Al exposure amplified reduction of these parameters. These results suggest that Al exposure via drinking water aggravates the impairment in hippocampal neurogenesis that is typically observed in type 2 diabetic animals.
- Subjects
DEVELOPMENTAL neurobiology; PHYSIOLOGICAL effects of aluminum; HIPPOCAMPUS physiology; ANIMAL diseases; CELL proliferation; CELL differentiation
- Publication
Journal of Veterinary Science, 2016, Vol 17, Issue 1, p13
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2016.17.1.13