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- Title
Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation.
- Authors
Chirou, María Niklison; Bellomio, Augusto; Dupuy, Fernando; Arcuri, Beatriz; Minahk, Carlos; Morero, Roberto
- Abstract
Microcin J25, an antimicrobial lasso-structure peptide, induces the opening of mitochondrial permeability transition pores and the subsequent loss of cytochrome c. The microcin J25 effect is mediated by the stimulation of superoxide anion overproduction. An increased uptake of calcium is also involved in this process. Additional studies with superoxide dismutase, ascorbic acid and different specific inhibitors, such as ruthenium red, cyclosporin A and Mn2+, allowed us to establish a time sequence of events starting with the binding of microcin J25, followed by superoxide anion overproduction, opening of mitochondrial permeability transition pores, mitochondrial swelling and the concomitant leakage of cytochrome c.
- Subjects
CYTOCHROME c; SUPEROXIDES; ANTI-infective agents; AMINO acids; PEPTIDES; SUPEROXIDE dismutase
- Publication
FEBS Journal, 2008, Vol 275, Issue 16, p4088
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2008.06550.x