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- Title
Transformation of Trifluorotoluenes Triggered by Titanium(IV) Chloride-Catalyzed Hydrodefluorination using Hydrosilanes.
- Authors
Yamada, Takayuki; Saito, Kodai; Akiyama, Takahiko
- Abstract
The titanium tetrachloride-catalyzed hydrodefluorination reaction of trifluorotoluene derivatives was developed using triethylsilane as the reducing agent. The reaction produced various toluene derivatives with high chemoselectivities by means of readily accessible reagents. This hydrodefluorination process was extended to the intramolecular Friedel-Crafts benzylation reaction, furnishing polycyclic aromatics of various ring sizes in good yields.
- Subjects
TOLUENE; TITANIUM tetrachloride; CHEMOSELECTIVITY; FRIEDEL-Crafts reaction; FLUORINATION
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 1, p62
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500920