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- Title
Two Consecutive Palladium(II)-Promoted CH Alkenylation Reactions for the Synthesis of 3-Alkenylquinolones.
- Authors
Ortiz ‐ de ‐ Elguea, Verónica; Sotomayor, Nuria; Lete, Esther
- Abstract
Highly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)-catalyzed CH alkenylation reactions. A selective 6- endo intramolecular CH alkenylation leads to 4-substituted quinolones that have been further functionalized at C-3 through a second intermolecular CH alkenylation reaction.
- Subjects
QUINOLONE antibacterial agents synthesis; ALKENYLATION; PALLADIUM; CARBON-hydrogen bonds; INTRAMOLECULAR catalysis
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 2/3, p463
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201400931