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- Title
The role of STAT3 in tumor-mediated immune suppression.
- Authors
Ferguson, Sherise; Srinivasan, Visish; Heimberger, Amy
- Abstract
The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.
- Subjects
STAT proteins; IMMUNOSUPPRESSION; IMMUNOREGULATION; CANCER invasiveness; HEALTH outcome assessment; GLIOBLASTOMA multiforme treatment
- Publication
Journal of Neuro-Oncology, 2015, Vol 123, Issue 3, p385
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-015-1731-3