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- Title
Improved molecular imaging contrast agent for detection of human thrombus.
- Authors
Patrick M. Winter; Shelton D. Caruthers; Xin Yu; Sheng-Kwei Song; Junjie Chen; Brad Miller; Jeff W.M. Bulte; J. David Robertson; Patrick J. Gaffney; Samuel A. Wickline; Gregory M. Lanza
- Abstract
Molecular imaging of microthrombus within fissures of unstable atherosclerotic plaques requires sensitive detection with a thrombus-specific agent. Effective molecular imaging has been previously demonstrated with fibrin-targeted Gd-DTPA-bis-oleate (BOA) nanoparticles. In this study, the relaxivity of an improved fibrin-targeted paramagnetic formulation, Gd-DTPA-phosphatidylethanolamine (PE), was compared with Gd-DTPA-BOA at 0.05-4.7 T. Ion- and particle-based r1 relaxivities (1.5 T) for Gd-DTPA-PE (33.7 (s*mM)-1 and 2.48 × 106 (s*mM)-1, respectively) were about twofold higher than for Gd-DTPA-BOA, perhaps due to faster water exchange with surface gadolinium. Gd-DTPA-PE nanoparticles bound to thrombus surfaces via anti-fibrin antibodies (1H10) induced 72% ± 5% higher change in R1 values at 1.5 T (ΔR1 = 0.77 ± 0.02 1/s) relative to Gd-DTPA-BOA (ΔR1 = 0.45 ± 0.02 1/s). These studies demonstrate marked improvement in a fibrin-specific molecular imaging agent that might allow sensitive, early detection of vascular microthrombi, the antecedent to stroke and heart attack. Magn Reson Med 50:411416, 2003. © 2003 Wiley-Liss, Inc.
- Subjects
ATHEROSCLEROTIC plaque; PHOSPHATIDYLETHANOLAMINES; NANOPARTICLES; GADOLINIUM; MYOCARDIAL infarction; FIBRIN; MEDICAL imaging systems
- Publication
Magnetic Resonance in Medicine, 2003, Vol 50, Issue 2, p411
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.10532