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- Title
Iridoid Glucosides with Free Radical Scavenging Properties from Fagraea blumei.
- Authors
Cuendet, Muriel; Hostettmann, Kurt; Potterat, Olivier; Dyatmiko, Wahjo
- Abstract
Four new iridoid glucosides 1- 4, named blumeosides A-D, were isolated from the methanolic stem-bark extract of Fagraea blumei G. D ON. (Loganiaceae). They were accompanied by the benzyl-alcohol derivative di- O-methylcrenatin ( 5) and the flavone C-glucoside swertisin ( 6). The structures of 1- 4 were established by spectroscopic methods, including FAB-MS, and 1H- and 13C-NMR, and by alkaline hydrolysis. Blumeosides A ( 1) and C ( 3) are 10- O-(2,5-dihydroxytercphthalo) adoxosidic acid and 10- O-(2-hydroxyterephthalo)adoxosidic acid, respectively. In blumeosides B ( 4) and D ( 2), both carboxylic groups of the terephthalic-acid moiety are esterified by adoxosidic-acid units, Blumeosides A-D ( 1- 4) inhibited bleaching of crocin induced by alkoxyl radicals. Blumeosides A ( 1) and D ( 2) also demonstrated scavenging properties towards the 2,2-diphenyl-1-picryl-hvdrazvl (CDPPH) radical in TLC autographic and spectrophotometric assays.
- Publication
Helvetica Chimica Acta, 1997, Vol 80, Issue 4, p1144
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19970800411