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- Title
Acute hypotension attenuates brachial flow-mediated dilation in young healthy men.
- Authors
Iwamoto, Erika; Yamada, Yutaka; Katayose, Masaki; Sakamoto, Rintaro; Neki, Toru; Sugawara, Jun; Ogoh, Shigehiko
- Abstract
<bold>Purpose: </bold>This study aimed to test our hypothesis that acute hypotension attenuates brachial flow-mediated dilation (FMD) as an index of endothelial function in healthy humans.<bold>Methods: </bold>Twelve healthy men (21.8 ± 1.6 years, body mass index; 22.2 ± 1.6 kg/m2) participated in this study. Brachial FMD was measured in three trials: standardized FMD protocol (control trial), abrupt decrease in blood pressure (BP) via thigh cuff inflation-deflation (hypotension trial) and decrease in shear rate (SR) via a shortened forearm occlusion time (SR reduction trial). Brachial diameter and blood velocity were measured using Duplex ultrasound.<bold>Results: </bold>Mean arterial pressure during reactive hyperaemia showed a marked decrease in the hypotension trial (- 23.7 ± 6.0 mmHg), but not in the control and SR reduction trials. SR area under the curve was attenuated in the SR reduction trial (P < 0.001), but not in the control and hypotension trials (P = 0.316). Consequently, FMD was attenuated in the hypotension and SR reduction trials compared with that in the control trial (P = 0.003 and P = 0.043, respectively), and was attenuated to a greater extent in the hypotension trial compared with the SR reduction trial (P = 0.006; control, 6.9 ± 3.5%; hypotension, 3.5 ± 1.7%; SR reduction, 5.0 ± 2.2%). After adjusting FMD using SR, FMD remained attenuated in the hypotension trial (P = 0.014), but not in the SR reduction trial.<bold>Conclusion: </bold>Our findings indicate that arterial pressure as well as sympathetic nervous system activation could be an important determinant of FMD. Blunted FMD of peripheral arteries may be a rational response to restore BP and/or prevent further reduction of BP following acute hypotension in healthy humans.
- Subjects
HYPOTENSION; SYMPATHETIC nervous system; BLOOD pressure; BODY mass index; YOUNG men; SYMPATHETIC nervous system physiology; BRACHIAL artery; ARTERIES; VASODILATION; BLOOD circulation; RESEARCH funding; STATISTICAL sampling
- Publication
European Journal of Applied Physiology, 2020, Vol 120, Issue 1, p161
- ISSN
1439-6319
- Publication type
journal article
- DOI
10.1007/s00421-019-04260-0