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- Title
Thrombosis-Inducing Activity in Plasma of Patients with Acute Respiratory Tract Infection Disappears after Treatment.
- Authors
Ogata, Kenichi; Yagawa, Katsuro; Hayashi, Shinichiro; Ogino, Hideo; Miyagawa, Yosuke; Miyazaki, Masayuki; Ichinose, Yukito; Koga, Toshihiko
- Abstract
Thrombosis-inducing activity (TIA) was identified in plasma from 16 of 27 patients (59%) with acute respiratory tract infections. On the other hand, it was present in only 9 of 79 subjects (11%) with chronic lung diseases and 4 of 49 healthy volunteers (8%). In the patients with acute resipratory tract infections, there were significant elevations in plasma fibrinogen, C-reactive protein and erythrocyte sedimentation rate in the TIA-positive group compared with the negative group. Plasma TIA disappeared in all of the 8 patients who were retested for TIA 2-5 weeks after they became disease free. Pneumonia was induced in rabbits by trans-bronchial injection of viable Escherichia coll TIA was not present in plasma from normal rabbits, but it appeared in plasma collected 3 days after injection. It then disappeared after 1-2 weeks of treatment with antibiotics. TIA may serve as a marker for inflammatory responses and be a factor responsible for elevated blood coagulation activity in patients with acute infectious diseases Copyright © 1991 S. Karger AG, Basel
- Publication
Respiration, 1991, Vol 58, Issue 3/4, p176
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000195922