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- Title
Development of a New Optical Device and Its Feasibility in Prostate Cancer Detection.
- Authors
Panteliou, Sofia D.; Tzortzis, Vassilios; Anagnostopoulos, George T.; Sunaric, M.M.; Sarris, J.; Hatzimouratidis, Konstantinos; Hatzichristou, Dimitris
- Abstract
Aim: To develop a new optical device (prostate optical device, POD) for assessment of prostate tissue stiffness and evaluate its sensitivity and specificity in prostate cancer detection. Patients and Methods: POD was tested in prostate phantoms and in patients with indications for prostate biopsy. Its sensitivity and specificity were compared to digital rectal examination (DRE) and transrectal ultrasonography (TRUS). Results: POD was able to identify stiffness differences on each prostate phantom. 45 patients were included in the study. Sensitivity of TRUS (40%) was significantly lower to POD (85.7%) and DRE (74.3%) (p = 0.000 and p = 0.003, respectively). There was no statistical difference between POD and DRE (p = 0.221). The combination of POD and DRE showed the highest sensitivity (88.6%), positive predictive value (81.6%), and negative predictive value (42.9%) among all diagnostic tests. Conclusions: POD identified prostatic stiffness differences with the same sensitivity of DRE performed by an experienced urologist providing an objective indication for prostate biopsy and early prostate cancer detection. Copyright © 2012 S. Karger AG, Basel
- Subjects
MEDICAL equipment; DIAGNOSIS; PROSTATE cancer; CANCER cells; ULTRASONIC imaging; IMAGING phantoms; FEASIBILITY studies
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 3, p290
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000339966